AI Article Synopsis
- Aberrant circRNA expression is linked to gastric cancer progression, but the underlying mechanisms are not fully understood.
- The study discovered a novel circRNA, hsa_circ_0069382, which is expressed at lower levels in gastric cancer tissues and regulates key factors involved in cancer aggression.
- Findings suggest that hsa_circ_0069382 could serve as a biomarker and therapeutic target by impacting cancer cell proliferation and migration through miR-15a-5p regulation.
Article Abstract
Aberrant expression of circRNAs is closely associated with the progression of gastric cancer; however, the specific mechanisms involved remain unclear. Our aim was to identify new gastric cancer biomarkers and explore the molecular mechanisms of gastric cancer progression. Therefore, we analyzed miRNA and circRNA microarrays of paired early-stage gastric cancer samples. Our study identified a new circRNA called hsa_circ_0069382, that had not been reported before and was expressed at low levels in gastric cancer tissues. Our study also included bioinformatics analyses which determined that the high expression of hsa_circ_0069382 regulated the BTG anti-proliferation factor 2 (BTG2)/ focal adhesion kinase (FAK) axis in gastric cancer lines by sponging for miR-15a-5p. Therefore, proliferation, invasion, and migration of gastric cancer is impacted. miR-15a-5p overexpression partially restored the effects of hsa_circ_0069382. This study provides potential new therapeutic options and a future direction to explore for gastric cancer treatment, and biomarkers.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960672 | PMC |
| http://dx.doi.org/10.1186/s12935-023-02871-4 | DOI Listing |
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