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Antifungal effects of thiosemicarbazone-chalcones on Aspergillus, Candida and Sporothrix strains.
Arch Microbiol
January 2025
Institute of Chemistry, Federal Rural University of Rio de Janeiro, BR 465, km 7, Seropedica, RJ, Brazil.
The frequency of opportunistic fungal infections has been increasing, impacting agriculture, food, and health sectors. In this work, four thiosemicarbazone-chalcones (TC) were synthesized and evaluated by the radial diffusion method against filamentous fungi. All TCs were effective against Aspergillus parasiticus, especially the fluor-substituted one, with radial growth inhibition of 62,9% and 74,4% at the lower (0.
View Article and Find Full Text PDFAnalyses of the Genetic Diversity and Population Structures of spp. Clinical Isolates from Paraíba, Brazil.
J Fungi (Basel)
December 2024
Laboratory of Mycology, Department of Pharmaceutical Sciences, Federal University of Paraiba (UFPB), João Pessoa 58051-900, Brazil.
Unlabelled: Sporotrichosis is a subcutaneous mycosis of global distribution, capable of affecting both humans and animals, and caused by species of the genus spp. This study aimed to evaluate the genetic diversity and mating type distribution of clinical isolates of human sporotrichosis in Paraíba, Brazil, to better understand the population structure, epidemiology, and diversification of this pathogen, as well as to explore possible transmission routes.
Methods: A total of 36 clinical isolates were morphologically identified, and clinical and demographic data were collected.
Sporothrix brasiliensis as the major causative species of the zoonotic outbreak of human sporotrichosis in the Brazilian Amazon.
Trop Med Int Health
January 2025
Programa de Pós-Graduação em Ciências Aplicadas à Dermatologia, Universidade do Estado do Amazonas, Manaus, Amazonas, Brazil.
Article Synopsis
- * A study in Manaus identified that 89.3% of sporotrichosis patients had S. brasiliensis, primarily impacting women with an average age of 44.5 years, and many reported prior contact with cats.
- * The research concluded that cats are major vectors for this zoonotic disease in the Amazon, emphasizing the need for sanitation, education, and responsible pet ownership to control its spread.
Evidence of Clinical and Laboratory Correlation of Itraconazole Resistance in Infection: Case Report.
Microorganisms
October 2024
Laboratory of Medical Mycology LIM-53, Clinical Dermatology Division, Hospital das Clínicas FMUSP, Faculdade de Medicina FMUSP, Institute of Tropical Medicine, University of São Paulo, São Paulo 05403000, Brazil.
Sporotrichosis is a subcutaneous infection caused by fungi from the genus , among which displays high virulence and transmissibility. So far, classical antifungal agents have been efficient against , but here we describe the first case of therapeutic failure and a high minimum inhibitory concentration (MIC) in relation to itraconazole.
View Article and Find Full Text PDFPhotodynamic therapy reduces viability, enhances itraconazole activity, and impairs mitochondrial physiology of Sporothrix brasiliensis.
Microbes Infect
November 2024
Laboratório de Biofísica de Fungos, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Rede Micologia RJ - FAPERJ, Rio de Janeiro, Brazil. Electronic address:
Sporothrix brasiliensis is the main agent of sporotrichosis in Brazil, with few therapeutic options. This study aimed to investigate the in vitro efficacy of photodynamic therapy using a diode laser (InGaAIP) in combination with the photosensitizer methylene blue against S. brasiliensis yeasts.
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