AI Article Synopsis
- This study explored how grape seed essential oil (GCEO) affects anxiety and memory issues caused by scopolamine (SCOP) in zebrafish, with GCEO showing significant improvement in both areas.
- The chemical analysis of GCEO revealed that limonene was the primary component, along with others like α- and β-pinene, which may contribute to its effects.
- Results indicated that GCEO reduced oxidative damage and improved cholinergic system function by lowering acetylcholinesterase (AChE) activity, suggesting its potential therapeutic role in memory impairment.
Article Abstract
The purpose of this study was to investigate the effect of essential oil (GCEO, 25 and 150 µL/L) on anxiety and learning and memory impairment induced by scopolamine (SCOP) in zebrafish. The chemical composition was analyzed by GC-MS, and the results showed that the highest content was limonene followed by α- and β-pinene, p-cymene and α-phellandrene. The dementia model was induced by SCOP (100 µM), whereas GCEO and galantamine (GAL, 1 mg/L) were delivered to the SCOP-induced model. It was found that GCEO significantly improved memory impairment and anxiety-like response induced by SCOP through the Y-maze, novel object recognition (NOR) test, and novel tank diving tests (NTT). Biochemical analyses showed that GCEO reduced SCOP-induced oxidative damage. Additionally, the cholinergic system activity was improved in the SCOP-induced model by decreasing the acetylcholinesterase (AChE) activity following the exposure to GCEO. It was clear that as a mixture, GCEO displays positive action in improving memory impairment through restoring cholinergic dysfunction and brain antioxidant status.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960976 | PMC |
| http://dx.doi.org/10.3390/plants12040784 | DOI Listing |
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