Cutaneous and Pulmonary Tuberculosis-Diagnostic and Therapeutic Difficulties in a Patient with Autoimmunity.

Pathogens

Department of Clinical Immunology and Pulmonary Disease, Lower Silesian Oncology, Pulmonology and Hematology Centre, P.O. Box 1818, 50-385 Wroclaw, Poland.

Published: February 2023

Cutaneous tuberculosis (CTB) is a very rare disease and accounts for only 1-2% of cases of extrapulmonary tuberculosis (EPTB). Due to the variety of its clinical manifestations, the uncharacteristic appearance of its lesions, resembling other dermatoses in the early stages, and the limited experience of clinicians due to the rarity of CTB, diagnosis is very difficult. Particularly noteworthy is the fact that most cases of EPTB, including skin tuberculosis (TB), can be a manifestation of systemic involvement. In this paper, we present a case of an immunocompromised patient who was diagnosed with CTB almost a year after the first dermatological lesions were located on the lower extremities. At the same time, due to respiratory symptoms, a diagnosis of pulmonary TB (PTB) was made, and radiological and microbiological confirmations were obtained.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959720PMC
http://dx.doi.org/10.3390/pathogens12020331DOI Listing

Publication Analysis

Top Keywords

cutaneous pulmonary
4
pulmonary tuberculosis-diagnostic
4
tuberculosis-diagnostic therapeutic
4
therapeutic difficulties
4
difficulties patient
4
patient autoimmunity
4
autoimmunity cutaneous
4
cutaneous tuberculosis
4
tuberculosis ctb
4
ctb rare
4

Similar Publications

To identify clusters of autoantibodies in a large cSLE population and to verify possible associations between different autoantibody clusters and the following variables: demographic data, cumulative clinical and laboratory manifestations, disease activity, cumulative damage and mortality. A cross-sectional study was performed in 27 Pediatric Rheumatology University centers, including 912 cSLE patients. The frequencies of seven selected autoantibodies (anti-dsDNA, anti-Ro/SSA, anti-La/SSB, anti-Sm, anti-RNP, aCL IgM and/or IgG and LA) were used for cluster analysis using the K-means method.

View Article and Find Full Text PDF

Pulmonary fibrosis as the sole manifestation of anti-Ku antibody positivity in the absence of myositis: A case report.

Respir Med Case Rep

January 2025

Department of Rheumatology of Lucania - UOSD of Rheumatology, "Madonna delle Grazie" Hospital, Matera, Italy.

Background: Anti-Ku antibodies are autoantibodies directed against the Ku protein complex involved in DNA repair. They are typically associated with overlap syndromes featuring polymyositis and systemic sclerosis. Isolated pulmonary involvement without myositis is exceedingly rare.

View Article and Find Full Text PDF

Systemic sclerosis sine (latin: without) scleroderma (ssSSc), also called visceral scleroderma, is characterized by internal organ involvement and abnormal serologic abnormalities in the complete or partial absence of cutaneous manifestations of systemic sclerosis.1,2 Pulmonary involvement in scleroderma consists of interstitial lung disease and pulmonary hypertension. Usual interstitial pneumonia (45.

View Article and Find Full Text PDF

Phosphodiesterase-4 (PDE4) is involved in the synthesis of inflammatory cytokines that mediate several chronic inflammatory disorders, including psoriasis and atopic dermatitis. In recent years, the therapeutic armamentarium in dermatology has expanded with the introduction of PDE4 inhibitors, both in oral and topical formulations. PDE4 inhibitors have gained increasing interest due to their remarkable safety record and ease of prescription, as evidenced by the recent influx of literature detailing its off-label uses.

View Article and Find Full Text PDF

An 89-year-old male with a medical history of non-ischemic cardiomyopathy was initially admitted with acute hypoxic respiratory failure attributed to heart failure exacerbation. Aside from progressive dyspnea, a non-pruritic, non-painful rash and constitutional symptoms were reported. Initial work-up was remarkable for normocytic anemia, lymphopenia, mild hypercalcemia, and elevated inflammatory markers.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!