AI Article Synopsis
- The study examines the impact of nutritional status (NS) on health-related quality of life (HRQoL) and overall survival (OS) in patients with metastatic castrate-resistant prostate cancer (mCRPC).
- At enrollment, patients were categorized into four NS groups: well-nourished, nutritional risk without sarcopenia/cachexia, sarcopenia, and cachexia.
- While initial results indicated that poorer nutritional status was linked to worse HRQoL and shorter OS, further analysis did not establish a significant influence of NS on these outcomes, suggesting a need for more intervention-focused research.
Article Abstract
Purpose: Prognostic role of nutritional status (NS) in patients with metastatic castrate-resistant prostate cancer (mCRPC) is unknown. We hypothesized that patients' NS at the presentation of mCRPC is prognostic for health-related quality of life (HRQoL) and overall survival (OS).
Methods: We conducted a prospective observational study in mCRPC patients. At enrollment, we allocated each patient into one of four NS categories: (i) well-nourished (WN), (ii) nutritional risk without sarcopenia/cachexia (NR), (iii) sarcopenia, or (iv) cachexia. We sought the prognostic role of the NS for OS and HRQoL by regression models.
Results: 141 patients were included into our study. When compared to WN patients, those with NR and cachexia had a higher chance of worse HRQoL (OR 3.45; 95% CI [1.28 to 9.09], and OR 4.17; 95% CI [1.28 to 12.5], respectively), as well as shorter OS (HR 2.04; 95% CI [1.19 to 3.39] and HR 2.9; 95% CI [1.56 to 5.41], respectively). However, when accounting for possible confounding factors, we could not prove the significant importance of NS for chosen outcomes.
Conclusions: Suboptimal NS might be an unfavorable prognostic factor for HRQoL and OS. Further interventional studies focusing on therapy or prevention are warranted.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964768 | PMC |
| http://dx.doi.org/10.3390/nu15041044 | DOI Listing |
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