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The Role of Consumption of Molybdenum Biofortified Crops in Bone Homeostasis and Healthy Aging. | LitMetric

The Role of Consumption of Molybdenum Biofortified Crops in Bone Homeostasis and Healthy Aging.

Nutrients

Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, 90133 Palermo, Italy.

Published: February 2023

AI Article Synopsis

  • - The study investigates how consuming molybdenum (Mo)-biofortified crops, specifically lettuce, affects bone health in adults and seniors, linking it to osteoporosis, a common issue in aging populations.
  • - Participants were divided into three groups: one consuming Mo-biofortified lettuce, one consuming regular lettuce, and one taking Mo tablets, with blood samples taken before and after the 12-day trial to assess bone metabolism markers.
  • - Results showed that Mo-biofortified lettuce significantly decreased markers of bone degradation and enhanced vitamin D levels, suggesting its potential as a beneficial dietary intervention for improving bone health in older adults.

Article Abstract

Osteoporosis is a chronic disease and public health issue in aging populations. Inadequate intake of micronutrients increases the risk of bone loss during an adult's lifespan and therefore of osteoporosis. The aim of the study was to analyze the effects of consumption of biofortified crops with the micronutrient molybdenum (Mo) on bone remodeling and metabolism in a population of adults and seniors. The trial enrolled 42 senior and 42 adult people randomly divided into three groups that consumed lettuce biofortified with molybdenum (Mo-biofortified group) or without biofortification (control group) or molybdenum in a tablet (Mo-tablet group) for 12 days. We chose an experimental period of 12 days because the bone remodeling marker levels are influenced in the short term. Therefore, a period of 12 days allows us to determine if there are changes in the indicators. Blood samples, obtained at time zero and at the end of the study, were compared within the groups adults and seniors for the markers of bone resorption, -terminal telopeptide (CTX) and bone formation osteocalcin, along with the markers of bone metabolism, parathyroid hormone (PTH), calcitonin, albumin-adjusted calcium, vitamin D, phosphate and potassium. Consumption of a Mo tablet did not affect bone metabolism in the study. Consumption of Mo-biofortified lettuce significantly reduced levels of CTX and PTH and increased vitamin D in adults and seniors while levels of osteocalcin, calcitonin, calcium, potassium and phosphate were not affected. The study opens up new considerations about the role of nutrition and supplementation in the prevention of chronic diseases in middle-aged and older adults. Consumption of Mo-biofortified lettuce positively impacts bone metabolism in middle-aged and older adults through reduced bone resorption and improved bone metabolism while supplementation of Mo tablets did not affect bone remodeling or metabolism. Therefore, Mo-biofortified lettuce may be used as a nutrition intervention to improve bone homeostasis and prevent the occurrence of osteoporosis in the elderly.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960304PMC
http://dx.doi.org/10.3390/nu15041022DOI Listing

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