AI Article Synopsis
- Cedryl acetate (CA) is an FDA-approved flavoring agent that was studied for its potential to prevent obesity and metabolic syndrome triggered by a high-fat diet (HFD).
- In a 19-week study with three groups of mice, CA supplementation significantly reduced weight gain, visceral fat, and prevented the enlargement of fat cells, while also improving liver and glucose metabolism.
- Despite no major changes detected in gut microbiota composition between the CA and HFD groups, the metabolic benefits of CA were linked to its influence on gene expression related to metabolism in liver and adipose tissues, suggesting its potential as a dietary intervention for obesity.
Article Abstract
Cedryl acetate (CA), also called acetyl cedrene, is approved by the FDA as a flavoring or adjuvant to be added to foods. In this study, we aimed to investigate the preventive benefits of CA on obesity and obesity-related metabolic syndrome caused by a high-fat diet (HFD). Three groups of C57BL/6J mice (ten-week-old) were fed Chow, an HFD, or an HFD with CA supplementation (100 mg/kg) for 19 weeks. We observed that CA supplementation significantly reduced weight gain induced by an HFD, decreased the weight of the visceral fat pads, and prevented adipocyte hypertrophy in mice. Moreover, mice in the CA group showed significant improvements in hepatic lipid accumulation, glucose intolerance, insulin resistance, and gluconeogenesis compared with the mice in the HFD group. Since 16S rRNA analysis revealed that the gut microbiota in the CA and HFD groups were of similar compositions at the phylum and family levels, CA may have limited effects on gut microbiota in HFD-fed mice. The beneficial effects on the metabolic parameters of CA were reflected by CA's regulation of metabolism-related gene expression in the liver (including , , and ) and the epididymal white adipose tissues (including , , , , , , , and ) of the mice. In summary, a potent preventive effect of CA on HFD-induced obesity and related metabolic syndrome was highlighted by our results, and CA could be a promising dietary component for obesity intervention.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967006 | PMC |
| http://dx.doi.org/10.3390/nu15040980 | DOI Listing |
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