AI Article Synopsis
- Vitamin B12 deficiency contributes to oxidative stress, linked to neurodegenerative diseases like Alzheimer's, while mogrosides, plant-derived compounds, show potential anti-inflammatory and antioxidant properties.
- The study explored mogrosides' protective effects in two types of C. elegans worms: vitamin B12-deficient wild-type N2 and transgenic CL2355, which expresses amyloid-β peptide associated with Alzheimer's.
- Findings suggested mogrosides improved the lifespan and reproductive rates of N2 worms and delayed paralysis in CL2355, indicating their role in enhancing oxidative protective gene expression rather than providing a cure for vitamin B12 deficiency.
Article Abstract
Vitamin B12 deficiency can lead to oxidative stress, which is known to be involved in neurodegenerative diseases such as Alzheimer's disease (AD). Mogrosides are plant-derived triterpene glycosides that exhibit anti-inflammatory and antioxidant activity in animal cell lines and mouse models. Since amyloid-β toxicity is known to cause oxidative stress and damage to brain cells, we hypothesized that mogrosides may have a protective effect against AD. In this study, we investigated the potential anti-AD effect of mogrosides in vitamin B12-deficient wild-type N2 and in transgenic CL2355 expressing amyloid-β peptide. Our data indicated that mogrosides have a beneficial effect on the lifespan and egg-laying rate of N2 and vitamin B12-deficient N2 worms. Additionally, the results revealed that mogrosides can effectively delay the paralysis of CL2355 worms as determined by serotonin sensitivity assay. Our analysis showed that mogrosides increase the expression of oxidative protective genes in N2 worms fed with vitamin B12-deficient OP50 bacterium. We conclude that mogrosides may exert preventative rather than curative effects that counteract the detrimental vitamin B12-deficient environment in N2 and CL2355 by modulating oxidation-related gene expression.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961707 | PMC |
| http://dx.doi.org/10.3390/molecules28041826 | DOI Listing |
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