In this work, 2-alkyl-10-chloro-1,2,3,4-tetrahydrobenzo[][1,6]naphthyridines were obtained and their reactivity was studied. Novel derivatives of the tricyclic scaffold, including 1-phenylethynyl (), 1-indol-3-yl (), and azocino[4,5-]quinoline () derivatives, were synthesized and characterized herein for the first time. Among the newly synthesized derivatives, - proved to be MAO B inhibitors with potency in the low micromolar range. In particular, the 1-(2-(4-fluorophenyl)ethynyl) analog achieved an IC of 1.35 μM, a value close to that of the well-known MAO B inhibitor pargyline.
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| http://dx.doi.org/10.3390/molecules28041662 | DOI Listing |
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