AI Article Synopsis
- The study explored how self-reported asthma affects testicular function by analyzing the semen and hormone levels of 6,177 men, some of whom reported asthma or allergy issues.
- Results showed that men with asthma generally had lower testicular function, particularly a significant decrease in total sperm count, but only a few results were statistically significant.
- The findings indicate that asthma is linked to poorer testicular function, but the study's design can't confirm whether asthma directly causes these issues.
Article Abstract
Asthma is driven by an inflammatory response that may impact testicular function. In this cross-sectional study, we investigated the association between self-reported asthma and testicular function (semen parameters, reproductive hormone levels), and determined whether potential further inflammation due to self-reported allergy modified this association. A total of 6177 men from the general population completed a questionnaire including information on doctor-diagnosed asthma or allergy, had a physical examination, delivered a semen sample, and had a blood sample drawn. Multiple linear regression analyses were performed. A total of 656 (10.6%) men reported having ever been diagnosed with asthma. Generally, self-reported asthma was consistently associated with a poorer testicular function; however, few estimates were statistically significant. Specifically, self-reported asthma was associated with statistically significant lower total sperm count [median: 133 vs. 145 million; adjusted β (95% CI): -0.18 (-0.33 to -0.04) million on cubic-root-transformed scale] and borderline statistically significant lower sperm concentration compared with no self-reported asthma. The association between asthma and total sperm count was of similar magnitude among men with and without allergy. In conclusion, men with self-reported asthma had poorer testicular function than men without asthma. However, the cross-sectional design of the study limits ascertainment of causality.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9966775 | PMC |
| http://dx.doi.org/10.3390/life13020278 | DOI Listing |
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