Background: Montgomery thyroplasty type I is a surgical technique indicated in vocal cord paralysis which consists of the paralyzed cord medialization, improving the voice quality. The objective of the study is to describe in detail the anesthetic method to obtain optimal post-medialization voice results.
Methodology: Retrospective case series study including patients who underwent medialization thyroplasty using the modified Montgomery technique at the General University Hospital of Valencia between 2011 and 2021. The anesthetic technique consisted of general anesthesia with neuromuscular relaxation and a laryngeal mask. Pre- and post-surgical vocal functional data of maximum phonation times (MPT), G score, and Voice Handicap Index-30 (VHI-30) were evaluated.
Results: All the patients presented an improvement in voice results, increasing MPT after surgery and a decrease in VHI-30 and G score postoperatively, with statistically significant differences between the pre- and post-surgical results (-value < 0.05). There were no complications related to anesthesia or surgery.
Conclusions: The use of general anesthesia with muscle relaxation in modified Montgomery thyroplasty may be a good option to consider. The use of a laryngeal mask for ventilation combined with a fiberoptic check allows direct visualization of the vocal cords intraoperatively, providing good functional voice results.
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http://dx.doi.org/10.3390/jpm13020194 | DOI Listing |
Eur J Contracept Reprod Health Care
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Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
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View Article and Find Full Text PDFBeilstein J Org Chem
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Department of Chemistry, University of Waterloo, 200 University Ave W., Waterloo, Ontario, Canada.
A novel study on the hypervalent iodine-mediated polyfluoroalkylation of sulfoxonium ylides was developed. Sulfoxonium ylides, known for their versatility and stability, are promising substrates for numerous transformations in synthetic chemistry. This report demonstrates the successful derivatization of sulfoxonium ylides with trifluoroethyl or tetrafluoropropyl groups, and provides valuable insights into the scope and limitations of this approach.
View Article and Find Full Text PDFmBio
December 2024
Department of Microbiology, New York University School of Medicine, New York, New York, USA.
Unlabelled: Upon entry into the upper respiratory tract (URT), (Spn) upregulates neuraminidases (NA) that cleave sialic acid (SA) from host glycans. Because sialylation is thought to contribute to the physical properties that determine mucus function, we posited that Spn directly alters host mucus through NA activity. By directly imaging the colonized URT, we demonstrated NA-mediated alterations to the characteristics and distribution of mucus along the respiratory epithelium, where colonizing bacteria are found.
View Article and Find Full Text PDFJ Clin Neurosci
December 2024
Anne Burnett Marion School of Medicine, Texas Christian University, 2800 South University Drive, Fort Worth, TX 76109, USA; Texas Health Physicians Group, 1325 Pennsylvania Ave, Fort Worth, TX 76104, USA.
Background: Frailty is a spectrum describing a demographic more likely to experience adverse events such as falls, disability, and hospital admission which can be quantified by the modified frailty index (mFI). Several studies have associated increased mFI score with higher rates of hospital readmission and length of stay (LOS). This study tests the predictive value of a frailty questionnaire based on the mFI on LOS and 30-day readmission rates.
View Article and Find Full Text PDFNEJM Evid
January 2025
Department of Psychiatry and School of Public Health, University of California, San Diego, La Jolla.
Background: Post-traumatic stress disorder (PTSD) is a serious, debilitating, and prevalent psychiatric condition occurring in people who are traumatized and experience intense, disturbing thoughts and feelings that persist. BNC210 is a novel α7 nicotinic acetylcholine receptor-negative allosteric modulator developed to treat PTSD.
Methods: ATTUNE was a randomized, double-blind, phase 2b, placebo-controlled trial.
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