Antibacterial Based Biocompatible Hydrogel for Use in Dermatological Applications.

The present research aims to describe a new methodology to obtain biocompatible hydrogels based on used for wound healing applications. The properties of two hydrogels (differing in concentration, AV5 and AV10) prepared by an all-green synthesis method from raw, natural, renewable and bioavailable materials such as salicylic acid, allantoin and xanthan gum were investigated. The morphology of the based hydrogel biomaterials was studied by SEM analysis. The rheological properties of the hydrogels, as well as their cell viability, biocompatibility and cytotoxicity, were determined. The antibacterial activity of based hydrogels was evaluated both on Gram-positive, and on Gram-negative, strains. The obtained novel green based hydrogels showed good antibacterial properties. In vitro scratch assay demonstrated the capacity of both AV5 and AV10 hydrogels to accelerate cell proliferation and migration and induce closure of a wounded area. A corroboration of all morphological, rheological, cytocompatibility and cell viability results indicates that this based hydrogel may be suitable for wound healing applications.