AI Article Synopsis
- Lipid-lowering therapies are crucial for preventing atherosclerotic cardiovascular disease (ASCVD) and reducing mortality, with ongoing research into their mechanisms of action using "omics" technologies.
- Pharmacometabolomics specifically examines how these therapies affect metabolic pathways, helping identify variations in treatment responses based on individual factors like disease and environment.
- Integrating pharmacometabolomics with other "omics" data could enhance our understanding of lipid-lowering drugs, paving the way for personalized medicine that improves treatment effectiveness and minimizes side effects.
Article Abstract
Lipid-lowering therapies are widely used to prevent the development of atherosclerotic cardiovascular disease (ASCVD) and related mortality worldwide. "Omics" technologies have been successfully applied in recent decades to investigate the mechanisms of action of these drugs, their pleiotropic effects, and their side effects, aiming to identify novel targets for future personalized medicine with an improvement of the efficacy and safety associated with the treatment. Pharmacometabolomics is a branch of metabolomics that is focused on the study of drug effects on metabolic pathways that are implicated in the variation of response to the treatment considering also the influences from a specific disease, environment, and concomitant pharmacological therapies. In this review, we summarized the most significant metabolomic studies on the effects of lipid-lowering therapies, including the most commonly used statins and fibrates to novel drugs or nutraceutical approaches. The integration of pharmacometabolomics data with the information obtained from the other "omics" approaches could help in the comprehension of the biological mechanisms underlying the use of lipid-lowering drugs in view of defining a precision medicine to improve the efficacy and reduce the side effects associated with the treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960554 | PMC |
| http://dx.doi.org/10.3390/ijms24043291 | DOI Listing |
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