() bloodstream infections (BSIs) are among the most predominant causes of death in infants and children worldwide. NDM-5 (New Delhi Metallo-lactamase-5) is responsible for one of the main mechanisms of carbapenem resistance in . To analyze the phenotypic and genomic characteristics of NDM-5-producing from bloodstream infections (BSIs), a total of 114 strains was collected from a children's hospital in Jiangsu province, China. Eight -carrying strains were identified which were all carbapenem-resistant and carried diverse antimicrobial resistance genes apart from . They belonged to six distinct sequence types (STs) and serotypes including one each for ST38/O7:H8, ST58/O?:H37, ST131/O25:H4, ST156/O11:H25 and ST361/O9:H30 and three strains are originating from a single clone belonging to ST410/O?:H9. Apart from , the strains isolated from BSIs also carried other β-lactamase genes, including ( = 4), ( = 2), ( = 3), ( = 1), ( = 4) and ( = 5). The genes were located on three different types of plasmids, which were IncFII/I1 ( = 1), IncX3 ( = 4) and IncFIA/FIB/FII/Q1 ( = 3). The former two types were conjugatively transferable at frequencies of 10 and 10, respectively. The dissemination of NDM-producing strains, which exhibit resistance to the last-line antibiotics, carbapenems, may increase the muti-antimicrobial resistance burden among BSIs and further threaten public health.
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| http://dx.doi.org/10.3390/genes14020520 | DOI Listing |
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