AI Article Synopsis
- The study evaluated the effectiveness of multiparametric breast MRI (mpMRI) in predicting how well luminal B subtype breast cancer patients respond to neoadjuvant chemotherapy (NAC).
- It involved 35 patients at a Zagreb hospital, who underwent mpMRI scans before and after receiving two cycles of NAC, analyzing both morphological and kinetic features of the tumors.
- The findings showed that a lack of decrease in the Göttingen score (GS) after treatment correlated with being a non-responder to NAC, as indicated by the cancer burden grading system.
Article Abstract
This study aimed to evaluate the performance of multiparametric breast magnetic resonance imaging (mpMRI) for predicting response to neoadjuvant chemotherapy (NAC) in patients with luminal B subtype breast cancer. The prospective study included thirty-five patients treated with NAC for both early and locally advanced breast cancer of the luminal B subtype at the University Hospital Centre Zagreb between January 2015 and December 2018. All patients underwent breast mpMRI before and after two cycles of NAC. Evaluation of mpMRI examinations included analysis of both morphological (shape, margins, and pattern of enhancement) and kinetic characteristics (initial signal increase and post-initial behavior of the time-signal intensity curve), which were additionally interpreted with a Göttingen score (GS). Histopathological analysis of surgical specimens included grading the tumor response based on the residual cancer burden (RCB) grading system and revealed 29 NAC responders (RCB-0 (pCR), I, II) and 6 NAC non-responders (RCB-III). Changes in GS were compared with RCB classes. A lack of GS decrease after the second cycle of NAC is associated with RCB class and non-responders to NAC.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9955433 | PMC |
| http://dx.doi.org/10.3390/diagnostics13040694 | DOI Listing |
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