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Pharmaco-Toxicological Effects of Atypical Synthetic Cathinone Mephtetramine (MTTA) in Mice: Possible Reasons for Its Brief Appearance over NPSs Scene. | LitMetric

AI Article Synopsis

  • The popularity of synthetic cathinones, especially mephtetramine (MTTA), is increasing among young adults in the illicit drug market due to their ability to mimic traditional stimulants like cocaine and MDMA.
  • This study evaluated the effects of repeated MTTA administration in mice, revealing sensory alterations, decreased breath rate and temperature, and variable effects on motor activity depending on the dose.
  • Analysis of blood and urine samples indicated significant toxicity, showing changes in blood cell counts and adverse histological effects on vital organs like the heart, kidneys, and liver.

Article Abstract

Over the last year, NPSs have been steadily on the rise in the illicit drug market. Among these, synthetic cathinones seem to become increasingly popular among young adults, mainly because of their ability to replicate the effects of traditional psychostimulant drugs, such as cocaine, MDMA and amphetamines. However, scarce data are available about the in vivo pharmaco-toxicology of these new substances. To this end, this study focused on evaluation of effects induced by repeated administration of mephtetramine (MTTA 0.1-30 mg/kg i.p.) in mice. This atypical cathinone highlighted a sensorial (inhibition of visual and acoustic reflexes) and transient physiological parameter (decrease in breath rate and temperature) change in mice. Regarding motor activity, both a dose-dependent increase (accelerod test) and biphasic effect (drag and mobility time test) have been shown. In addition, blood and urine samples have been analysed to enrich the experimental featuring of the present study with reference to evaluation of potential toxicity related to consumption of MTTA. The latter analysis has particularly revealed important changes in blood cells count and blood and urine physicochemical profile after repeated treatment with this atypical cathinone. Moreover, MTTA induced histological changes in heart, kidney and liver samples, emphasizing its potential toxicity.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954072PMC
http://dx.doi.org/10.3390/brainsci13020161DOI Listing

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