AI Article Synopsis
- Progress has been made in understanding how aging of adipose stem cells (ASCs) contributes to diseases like obesity by disrupting normal fat cell formation.
- The review highlights factors that lead to ASC failure in developing into fat cells, including changes in cell signaling, genetics, metabolism, and physical exertion.
- Researchers suggest that enhancing the ability of ASCs to become fat cells could be a promising strategy for treating obesity and improving metabolic health.
Article Abstract
Progress has been made in identifying stem cell aging as a pathological manifestation of a variety of diseases, including obesity. Adipose stem cells (ASCs) play a core role in adipocyte turnover, which maintains tissue homeostasis. Given aberrant lineage determination as a feature of stem cell aging, failure in adipogenesis is a culprit of adipose hypertrophy, resulting in adiposopathy and related complications. In this review, we elucidate how ASC fails in entering adipogenic lineage, with a specific focus on extracellular signaling pathways, epigenetic drift, metabolic reprogramming, and mechanical stretch. Nonetheless, such detrimental alternations can be reversed by guiding ASCs towards adipogenesis. Considering the pathological role of ASC aging in obesity, targeting adipogenesis as an anti-obesity treatment will be a key area of future research, and a strategy to rejuvenate tissue stem cell will be capable of alleviating metabolic syndrome.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954614 | PMC |
| http://dx.doi.org/10.3390/cells12040662 | DOI Listing |
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