AI Article Synopsis
- Preeclampsia is a common pregnancy-related condition characterized by high blood pressure and protein in the urine, posing risks to both mothers and babies.
- Research indicates that peroxisome proliferator-activated receptors (PPARs), proteins that regulate gene expression, may be involved in the causes of preeclampsia.
- A review of studies found mixed results regarding PPAR expression in affected placentas, but suggested that PPARγ agonists could offer new treatment options for managing preeclampsia.
Article Abstract
Preeclampsia is a common pregnancy-related hypertensive disorder. Often presenting as preexisting or new-onset hypertension complicated by proteinuria and/or end-organ dysfunction, preeclampsia significantly correlates with maternal and perinatal morbidity and mortality. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor proteins that regulate gene expression. In order to investigate the role of PPARs in the pathophysiology of preeclampsia, we conducted a literature review using the MEDLINE and LIVIVO databases. The search terms "peroxisome proliferator-activated receptor", "PPAR", and "preeclampsia" were employed and we were able to identify 35 relevant studies published between 2002 and 2022. Different study groups reached contradictory conclusions in terms of PPAR expression in preeclamptic placentae. Interestingly, PPARγ agonists alone, or in combination with well-established pharmaceutical agents, were determined to represent novel, potent anti-preeclamptic treatment alternatives. In conclusion, PPARs seem to play a significant role in preeclampsia.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9954398 | PMC |
| http://dx.doi.org/10.3390/cells12040647 | DOI Listing |
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