When considering two dichotomous tests in combination for reaching a treatment decision, the choice between single and multiple testing depends, in part, on the pretest probability of disease. The authors show that two tests are never preferred to a single test for all disease probabilities, regardless of whether the two tests are performed in parallel or in series.
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http://dx.doi.org/10.1177/0272989X8700700403 | DOI Listing |
Orphanet J Rare Dis
January 2025
Institute of Human Genetics, Leipzig University Medical Center, Leipzig, Germany.
Background: Cardiac rhabdomyoma (RHM) is considered one of the most frequent benign heart tumors in children. However, encounters with cardiac RHM in clinical practice remain rare. Clinical information is primarily available in the form of single case reports or smaller studies with a shortage of large-scale reviews encompassing a substantial number of cases.
View Article and Find Full Text PDFBMC Genomics
January 2025
School of Life Sciences, Yunnan Normal University, Kunming, 650000, China.
Background: Pseudogalium is a new monotypic genus with two subspecies in China and one in Japan, which holds a distinctive phylogenetic position and ecological significance within the tribe Rubieae. Chloroplast genomes contain abundant information for resolving phylogenetic relationships. To investigate the phylogenetics of P.
View Article and Find Full Text PDFSci Rep
January 2025
School of Physics, Xi'an Jiaotong University, No.28 Xianning West Road, Xi'an, 710049, Shaanxi, P. R. China.
Deep reinforcement learning is considered an effective technology in quantum optimization and can provide strategies for optimal control of complex quantum systems. More precise measurements require simulation control at multiple experimental stages. Based on this, we improved a multi-objective deep reinforcement learning method in mathematical convex optimization theory for multi-process quantum optimal control optimization.
View Article and Find Full Text PDFReprod Sci
January 2025
Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
The metabolomic approach has recently been used in the assessment of semen quality and male fertility. Additionally, the crucial roles of branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) in metabolic syndrome (MetS) were reported. However, little information exists about the association between BCAAs and AAAs with semen parameters, particularly in men with and without MetS.
View Article and Find Full Text PDFPediatr Cardiol
January 2025
Division of Cardiology, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA.
L-transposition of the great arteries (L-TGA) represents a spectrum of congenital heart defects (CHD) associated with atrioventricular block (AVB). However, the incidence and prognosis of postoperative AVB among patients with variants of L-TGA is uncertain. Assess the incidence and risk factors for postoperative AVB requiring permanent pacemaker (PPM) implantation for pediatric patients with L-TGA undergoing cardiac surgery.
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