Two Operational Modes of Cardio-Respiratory Coupling Revealed by Pulse-Respiration Quotient.

Due to the fact that respiratory breath-to-breath and cardiac intervals between two successive R peaks ( and , respectively) are not temporally concurrent, in a previous paper, we proposed a method to calculate both the integer and non-integer parts of the pulse respiration quotient ( = / = + + ), and being parts of the border for each . In this work, we study the correlations between and , as well as those between and mean within each (), on a group of twenty subjects in four conditions: in supine and standing positions, in combination with spontaneous and slow breathing. Results show that the vs. correlations are positive; whereas the breathing regime had little or no effect on the linear regression slopes, body posture did. Two types of scatter plots were obtained with the vs. correlations: one showed points aggregated around the concurrent lines, while the other showed randomly distributed points. Five out of six of the proposed aggregation measures confirmed the existence of these two cardio-respiratory coupling regimes. We also used to study the positions of R pulses relative to the respiration onsets and showed that they were more synchronous with sympathetic activation. Overall, this method should be used in different pathological states.