AI Article Synopsis
- Undernourishment during pregnancy leads to metabolic disorders in female offspring (F1) and can also affect their future offspring (F2) in a mouse model study.
- The study found that poor nutrition in utero reduces global DNA methylation in F1 female oocytes, specifically impacting genes tied to metabolism.
- The results suggest that altered DNA methylation patterns in F1 females are inherited by F2 females, which may contribute to the development of metabolic disorders across generations.
Article Abstract
Background: Undernourishment in utero has deleterious effects on the metabolism of offspring, but the mechanism of the transgenerational transmission of metabolic disorders is not well known. In the present study, we found that undernourishment in utero resulted in metabolic disorders of female F1 and F2 in mouse model.
Results: Undernutrition in utero induced metabolic disorders of F1 females, which was transmitted to F2 females. The global methylation in oocytes of F1 exposed to undernutrition in utero was decreased compared with the control. KEGG analysis showed that genes with differential methylation regions (DMRs) in promoters were significantly enriched in metabolic pathways. The altered methylation of some DMRs in F1 oocytes located at the promoters of metabolic-related genes were partially observed in F2 tissues, and the expressions of these genes were also changed. Meanwhile, the abnormal DNA methylation of the validated DMRs in F1 oocytes was also observed in F2 oocytes.
Conclusions: These results indicate that DNA methylation may mediate the transgenerational inheritance of metabolic disorders induced by undernourishment in utero via female germline.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960220 | PMC |
| http://dx.doi.org/10.1186/s12915-023-01545-x | DOI Listing |
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