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A Single-Group Study on the Effect of OnabotulinumtoxinA in Patients with Chronic Migraine Associated with Medication Overuse Headache: Pain Catastrophizing Plays a Role. | LitMetric

AI Article Synopsis

  • Pain catastrophizing and cutaneous allodynia are common issues in patients with chronic migraines linked to medication overuse, and their improvement is associated with overall clinical recovery.
  • In a study involving 96 patients receiving OnabotulinumtoxinA therapy, significant improvements were observed in headache frequency, medication usage, and disability within six months, with effects sustained over 12 months.
  • The reduction in pain catastrophizing, particularly related to feelings of helplessness, was identified as a predictor for lower headache frequency and decreased medication intake, suggesting that combining OnabotulinumtoxinA with behavioral treatments targeting pain catastrophizing could optimize patient outcomes.

Article Abstract

Pain catastrophizing and cutaneous allodynia are commonly altered in patients with chronic migraine associated with medication overuse headache (CM-MOH) and tend to improve in parallel with clinical improvement. The relation between pain catastrophizing and cutaneous allodynia is poorly understood in patients with CM-MOH receiving OnabotulinumtoxinA therapy. In this single-arm open-label longitudinal observational study, patients with CM-MOH were assigned to structured withdrawal and then administered OnabotulinumtoxinA (5 sessions on a three-month basis, 195 UI per 31 sites). Headache frequency, medication intake, disability, impact, cutaneous allodynia and pain catastrophizing were evaluated with specific questionnaires. In total, 96 patients were enrolled and 79 completed the 12-month follow-up. With the exclusion of cutaneous allodynia and the magnification subscale of the pain catastrophizing questionnaire, all variables showed significant improvement by the sixth month, which was maintained at 12 months. Reduction of pain catastrophizing, and particularly of its helplessness subscale, was a significant predictor of reduction in headache frequency and medication intake. Pain catastrophizing is often implicated in the clinical improvement in patients with CM-MOH receiving behavioral treatments, but, in this study, also showed a role in patients receiving OnabotulinumtoxinA; combining OnabotulinumtoxinA and behavioral treatments specifically addressing pain catastrophizing might further enhance patients' clinical outcome.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9967692PMC
http://dx.doi.org/10.3390/toxins15020086DOI Listing

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