Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1152/ajpheart.00093.2023 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
HIF-1α knockdown attenuates phenotypic transformation and oxidative stress induced by high salt in human aortic vascular smooth muscle cells.
Sci Rep
November 2024
Department of Geriatrics, The First Affiliated Hospital of Dali University, Dali, 671000, Yunnan, China.
Increased dietary salt intake is a well-established risk factor for hypertension and related cardiovascular diseases, involving complex vascular remodeling processes. However, the specific role of hypoxia-inducible factor-1α (HIF-1α) in vascular pathophysiology under high-salt conditions remains poorly understood. This study investigates the role of HIF-1α in high-salt-induced vascular remodeling using human aortic vascular smooth muscle cells (HA-VSMCs) cultured in vitro.
View Article and Find Full Text PDFA novel model of cardiovascular-kidney-metabolic syndrome combining unilateral nephrectomy and high-salt-sugar-fat diet in mice.
Lab Anim (NY)
November 2024
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
The aim of this study was to explore biological interaction and pathophysiology mechanisms in a new mouse model of cardiovascular-kidney-metabolic (CKM) syndrome, induced by chronic moderate renal failure in combination with consumption of a customized Western diet rich in carbohydrates, fat and salt. Male C57BL/6J mice were subjected to unilateral nephrectomy, fed a customized Western diet rich not only in sugar and fat but also in salt, and followed for 12 weeks or 20 weeks. Sham-operated mice on a standard chow served as healthy controls.
View Article and Find Full Text PDFPlacenta may exert fetal protection against maternal high salt diet intake via renin-angiotensin-aldosterone system.
Placenta
December 2024
Department of Physiology and Immunology, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Scientific Center of Excellence for Personalized Health Care, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia. Electronic address:
Objective: This study investigated the effects of high compared to normal dietary salt intake on fetoplacental vascular function, activity of renin-angiotensin-aldosterone system (RAAS), placental pro- and anti-angiogenic factors and biomarkers of placental remodeling and oxidative stress during healthy uncomplicated pregnancy.
Materials And Methods: Based on their 24-h sodium excretion pregnant women (37-40 weeks' gestation) were categorized into three groups: normal salt (NS, <5.75 g/day, N = 12), high salt (HS, 5.
Impact of inhibition of the renin-angiotensin system on early cardiac and renal abnormalities in Sprague Dawley rats fed short-term high fructose plus high salt diet.
Front Nutr
August 2024
Department of Physiology, Wayne State University, Detroit, MI, United States.
Introduction: The combination of a high fructose and high salt diet typical of western diet induces high blood pressure, aortic stiffening, left ventricular (LV) diastolic dysfunction and impaired renal function in rodents. Despite an activated renin-angiotensin system (RAS) in rats fed high fructose and high salt, acute inhibition of the RAS pathway does not improve cardiac and vascular parameters. It may well be that longer term treatment is required to permit remodeling and improve cardiovascular function.
View Article and Find Full Text PDFNephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats.
Respir Res
July 2024
State Key Laboratory of Respiratory Diseases, National Center for Respiratory Medicine, Guangdong Key Laboratory of Vascular Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou, 510120, Guangdong, China.
Article Synopsis
- Chronic kidney disease (CKD) increases the risk of developing pulmonary hypertension (PH), but the exact mechanisms behind this connection are not well understood and there is no reliable animal model for research.
- This study successfully created a stable rat model of CKD-PH by performing 5/6 nephrectomy combined with a high-salt diet, followed by dynamic evaluations of hemodynamics and pathological changes in various organs.
- Results indicated that CKD-PH rats exhibited significant pulmonary arterial hypertension, right ventricular hypertrophy, dysregulation of the renin-angiotensin-aldosterone system (RAAS), decreased ACE2 expression in the lung endothelium, and distinct serum metabolic profiles compared to control rats.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!