AI Article Synopsis
- Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common optic nerve disorder in adults over 50, caused by reduced blood flow to the optic nerve head, and is linked to changes in choroidal thickness.
- A meta-analysis of nine studies, involving 663 eyes, revealed that both macular choroidal thickness (MCT) and peripapillary choroidal thickness (PCT) were significantly higher in chronic NAION patients compared to healthy controls, but no differences were found in acute NAION cases.
- These findings suggest that increased MCT and PCT may serve as important indicators of the condition's anatomical and physiological changes in NAION patients.
Article Abstract
Background: Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common optic neuropathy in adults aged ≥ 50 years. Transient non-perfusion or hypoperfusion of the optic nerve head circulation is believed to be the underlying cause of NAION. It has been suggested that peripapillary choroidal thickness (PCT) is altered after ischemic disorders of the optic nerve head, but the results have not always been consistent. To address this issue and provide evidence for the pathogenesis of NAION, we performed a meta-analysis to systematically evaluate macular choroidal thickness (MCT) and PCT in patients with NAION.
Methods: A comprehensive literature search of PubMed, Embase, Cochrane Library, and Web of Science databases was performed until August 31, 2022. The main inclusion criterion was a case-control study in which MCT and PCT were measured using optical coherence tomography in patients with NAION. Mean difference (MD) and 95% confidence interval were calculated for continuous estimates. The Review Manager (V5.40) was used for the analysis.
Results: Nine studies comprising 663 eyes (283 NAION eyes and 380 healthy control eyes) were included (Newcastle-Ottawa Scale score ≥ 5). MCT and PCT were higher in eyes with chronic NAION (MD = 19.16, P = .04; MD = 35.36, P < .00001) and NAION fellow eyes (MD = 30.35, P = .0006; MD = 29.86, P = .04) than in healthy controls. No difference was noted in the MCT between eyes with acute NAION and healthy controls (MD = 2.99, P = .87).
Conclusion: Increased MCT and PCT may be important anatomical and physiological features of the eyes in patients with NAION.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11309611 | PMC |
| http://dx.doi.org/10.1097/MD.0000000000032916 | DOI Listing |
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