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Alginate Ag/AgCl Nanoparticles Composite Films for Wound Dressings with Antibiofilm and Antimicrobial Activities. | LitMetric

AI Article Synopsis

  • - Recent research has looked into using silver-based nanoparticles in wound dressings due to their ability to fight bacteria, but their toxicity to skin cells limits their application.
  • - A new method was developed to create alginate AgCl nanoparticle composite films that are antimicrobial and less harmful to skin cells through a process involving CaCl solution.
  • - The resulting films demonstrated effective antibacterial and antibiofilm properties while showing low cytotoxicity, particularly toward fibroblasts, making them a promising option for infection prevention in wound care.

Article Abstract

Recently, silver-based nanoparticles have been proposed as components of wound dressings due to their antimicrobial activity. Unfortunately, they are cytotoxic for keratinocytes and fibroblasts, and this limits their use. Less consideration has been given to the use of AgCl nanoparticles in wound dressings. In this paper, a sustainable preparation of alginate AgCl nanoparticles composite films by simultaneous alginate gelation and AgCl nanoparticle formation in the presence of CaCl solution is proposed with the aim of obtaining films with antimicrobial and antibiofilm activities and low cytotoxicity. First, AgNO alginate films were prepared, and then, gelation and nanoparticle formation were induced by film immersion in CaCl solution. Films characterization revealed the presence of both AgCl and metallic silver nanoparticles, which resulted as quite homogeneously distributed, and good hydration properties. Finally, films were tested for their antimicrobial and antibiofilm activities against (ATCC 12228), (ATCC 29213), (ATCC 15692), and the yeast . Composite films showed antibacterial and antibiofilm activities against the tested bacteria and resulted as less active towards . Film cytotoxicity was investigated towards human dermis fibroblasts (HuDe) and human skin keratinocytes (NCTC2544). Composite films showed low cytotoxicity, especially towards fibroblasts. Thus, the proposed sustainable approach allows to obtain composite films of Ag/AgCl alginate nanoparticles capable of preventing the onset of infections without showing high cytotoxicity for tissue cells.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9968148PMC
http://dx.doi.org/10.3390/jfb14020084DOI Listing

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