AI Article Synopsis
- Postoperative adhesion is a frequent complication after surgery, involving connective tissue formations that can impact recovery, but understanding its causes and effective prevention methods still requires more research.
- Hydrogels, which are water-absorbing polymers with a porous structure, can effectively carry and release drugs, showing promise in preventing these adhesions due to their strong antifouling properties.
- The review summarizes the latest findings on hydrogels as barriers against postoperative adhesions, highlights their key attributes, and suggests directions for future research in this area.
Article Abstract
Postoperative adhesion is a common post-surgery complication formed between the surface of the body cavity, ranging from a layer of connective tissue to a fibrous bridge containing blood vessels and nerve tissue. Despite achieving a lot of progress, the mechanisms of adhesion formation still need to be further studied. In addition, few current treatments are consistently effective in the prevention of postoperative adhesion. Hydrogel is a kind of water-expanding crosslinked hydrophilic polymer network generated by a simple reaction of one or more monomers. Due to the porous structure, hydrogels can load different drugs and control the drug release kinetics. Evidence from existing studies has confirmed the feasibility and superiority of using hydrogels to counter postoperative adhesions, primarily due to their outstanding antifouling ability. In this review, the current research status of hydrogels as anti-adhesion barriers is summarized, the character of hydrogels in the prevention of postoperative adhesion is briefly introduced, and future research directions are discussed.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9957106 | PMC |
| http://dx.doi.org/10.3390/gels9020098 | DOI Listing |
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