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Tandem mass tag-based quantitative proteomics and targeted hormone analysis reveal the response to insect herbivory stress in Ginseng (Panax ginseng, L.).
PLoS One
January 2025
Wuzhou University, College of Food and Pharmaceutical Engineering, Guangxi, P. R. China.
Ginsenosides are the most important secondary metabolites of ginseng. Ginseng has developed certain insect resistance properties during the course of evolutionary environmental adaptation. However, the mechanism underlying the insect resistance of ginseng is poorly understood.
View Article and Find Full Text PDFReevaluating gender-affirming care: biological foundations, ethical dilemmas, and the complexities of gender dysphoria.
J Sex Marital Ther
January 2025
Department of Interdisciplinary Studies, University of South Florida, Tampa, FL, USA.
This paper critically examines the scientific and ethical underpinnings of gender-affirming care, particularly for minors. While major medical organizations endorse such interventions as medically necessary, the evidence supporting their long-term safety and efficacy remains limited. Research into hormonal, neuroanatomic, and genetic influences reveals a strong biological basis for gender identity, challenging social constructionist arguments.
View Article and Find Full Text PDFSynthesis and characterization of heterotrimetallic Mg-Ni-Mg complexes with amidinato ligands.
Dalton Trans
January 2025
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China.
Treatment of amidinato-based magnesium ethyl compounds LMgEt [L = PrPNC(Bu)NAr; Ar = 2,6-PrCH (La) or 2,6-(PhCH)-4-Pr-(CH) (Lb)] with Ni(COD) (COD: 1,5-cyclooctadiene) afforded heterotrimetallic Mg-Ni-Mg complexes [(LMg)Ni(CH)] through β-H elimination. These complexes exhibit approximately linear Mg-Ni-Mg linkage with the central nickel arranged in a planar configuration; the Ni(CH) unit can be considered as nickela-bis-cyclopropane. Reaction of [(LMg)Ni(CH)] with tetrahydrofuran (THF) gave a coordination product [(LMg·THF)Ni(CH)], in which the central structure remained intact and THF coordinated to two magnesium atoms respectively.
View Article and Find Full Text PDFUnilateral Corneal Ectasia After Bilateral Transepithelial Photorefractive Keratectomy.
Cureus
December 2024
Department of Ophthalmology, The University of Jordan, Amman, JOR.
We present the case of a 23-year-old male who experienced vision loss in his left eye 15 months after undergoing bilateral transepithelial photorefractive keratectomy (T-PRK). Despite the absence of any significant preoperative topographical risk factors in either eye, corneal ectasia was later confirmed in the left eye, while the right eye remained normal. Subtle asymmetry in topometric indices and a borderline high Index of vertical asymmetry (IVA) reading suggested the possibility of early subclinical keratoconus, potentially increasing the risk of post-refractive ectasia.
View Article and Find Full Text PDFSevere aortic valve stenosis poses a significant risk for the aging population, often escalating from mild symptoms to life-threatening heart failure and sudden death. Without timely intervention, this condition can lead to disastrous outcomes. The advent of transcatheter aortic valve implantation (TAVI) has gained popularity, emerging as an effective alternative for managing severe aortic stenosis (AS) in high-risk patients experiencing deterioration of previously implanted bioprosthetic surgical aortic valves (SAV), which introduces complex challenges such as device compatibility and anatomical considerations.
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