Lewis base-catalyzed cascade nucleophilic/aza-Michael addition reaction of -alkoxy β-oxo-acrylamides with isocyanates has been developed to afford various highly functionalized hydantoin derivatives in 80-98% yields under mild reaction conditions. The intriguing features of this method include metal-free reaction conditions, low catalyst loading, broad substrate scope and short reaction time.
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Organocatalytic cascade nucleophilic/aza-Michael addition reactions: metal-free catalytic strategy for the synthesis of hydantoins.
Org Biomol Chem
March 2023
Address here. School of Pharmaceutical Sciences, College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252000, Shandong, P. R. China. xieleilcu.edu.cn.
Lewis base-catalyzed cascade nucleophilic/aza-Michael addition reaction of -alkoxy β-oxo-acrylamides with isocyanates has been developed to afford various highly functionalized hydantoin derivatives in 80-98% yields under mild reaction conditions. The intriguing features of this method include metal-free reaction conditions, low catalyst loading, broad substrate scope and short reaction time.
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