AI Article Synopsis
- The brain has a natural limit in its ability to heal itself after damage or disorders, making recovery challenging.
- Current cell and gene therapies show promise for treating brain issues, but relying on just one type of treatment is unlikely to be effective on its own.
- The article suggests that using a combination of therapies, alongside biomaterials, could improve the effectiveness of neurotherapeutics in overcoming existing limitations.
Article Abstract
The brain has limited innate ability to promote repair, regeneration and functional recovery following injury, disease, or developmental disorder. Although cell and gene therapies have significant potential in the brain, no single treatment is likely to succeed in isolation. Here we discuss the current state of the art in cell and nucleic-acid-based neurotherapeutics and argue for the development of combination therapies that use biomaterials to help overcome the current limitations of cell and gene therapies alone.
Download full-text PDF |
Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934481 | PMC |
| http://dx.doi.org/10.1016/j.bbiosy.2021.100036 | DOI Listing |
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