Association of LAMA1 Single-Nucleotide Polymorphisms with Risk of Esophageal Squamous Cell Carcinoma among the Eastern Chinese Population.

Introduction: LAMA1, also known as laminin subunit 1, is a member of the laminin family, which is widely reported to be a key basement membrane molecule that affects various biological activities and is associated with many kinds of diseases. We aimed to investigate the association between single-nucleotide polymorphisms and the occurrence and progression of esophageal squamous cell carcinoma in the Chinese population.

Method: 2,186 participants were collected retrospectively between October 2008 and January 2017, including 1,043 ESCC patients and 1,143 noncancer patients. A 2 mL blood sample was obtained intravenously for the LDR for SNP analysis. The 6 SNP loci of were selected and examined. We analyzed the association of several genetic models of 6 SNP loci, sex, age, smoking and drinking status, and the occurrence of esophageal squamous cell carcinoma.

Results: In the rs62081531 G > A locus, genotype GA was a protective factor for ESCC compared with GG (OR: 0.830, =0.046), especially among the younger and nondrinkers. At rs607230 T > C, genotype TC was linked with a lower risk of ESCC compared with TT. (OR: 0.613, =0.034). Haplotype Frequencies revealed that AGATAC (OR: 0.803, =0.028) and GGATCC (OR: 0.679, =0.010) were strongly associated with lower susceptibility of ESCC.

Conclusion: The rs62081531, rs539713, rs566655, and rs607230 polymorphisms were demonstrated to be related to susceptibility to ESCC in the Chinese population. SNPs may have a significant impact on the occurrence of esophageal cancer and may serve as potential diagnostic biomarkers.