AI Article Synopsis
- MAH is a significant cause of non-tuberculosis mycobacterial infections in both humans and pigs, with limited research on pig isolates despite their potential role in human infections.
- The study sequenced 30 draft genomes of MAH from pigs in Japan, revealing genome lengths ranging from 4.8 to 5.6 million base pairs, with thousands of coding genes and several predicted virulence factors.
- Findings from this research will aid in understanding MAH's ecology and support future genome-based epidemiological studies.
Article Abstract
subsp. (MAH) is one of the most important agents causing non-tuberculosis mycobacterial infection in humans and pigs. There have been advances in genome analysis of MAH from human isolates, but studies of isolates from pigs are limited despite its potential source of infection to human. Here, we obtained 30 draft genome sequences of MAH from pigs reared in Japan. The 30 draft genomes were 4,848,678-5,620,788 bp in length, comprising 4652-5388 coding genes and 46-75 (median: 47) tRNAs. All isolates had restriction modification-associated genes and 185-222 predicted virulence genes. Two isolates had tRNA arrays and one isolate had a clustered regularly interspaced short palindromic repeat (CRISPR) region. Our results will be useful for evaluation of the ecology of MAH by providing a foundation for genome-based epidemiological studies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650289 | PMC |
| http://dx.doi.org/10.46471/gigabyte.33 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!