AI Article Synopsis
- The case study investigates the connection between viral infections and collapsing focal segmental glomerulosclerosis (cFSGS) in kidney transplant patients.
- Three case reports illustrate how cFSGS developed after infections, including those from SARS-CoV-2, cytomegalovirus, and hepatitis B virus.
- The findings emphasize the need to consider viral causes in cFSGS, particularly among patients with weakened immune systems post-transplant.
Article Abstract
Background: The aim of this case study was to explore the possible link between viral infections and collapsing focal segmental glomerulosclerosis (cFSGS) in patients who underwent kidney transplantation.
Methods: This case study included 3 case reports of patients who underwent kidney transplantation. The case reports were presented clinically and pathohistologically with cFsGS as a possible consequence of viral infections.
Results: The first patient developed cFSGS after polymerase chain reaction for SARS-CoV2 was positive twice. He gradually developed terminal stage chronic kidney disease. The second patient developed cFSGS with high range proteinuria after cytomegalovirus infection, which has been treated with 3 lines of antiviral medicaments. The third patient developed cFSGS as a possible consequence of hepatitis B virus infection.
Conclusions: This case study highlighted the importance of viral etiology in the pathway of cFSGS. Pathogenic links between viral infections and concomitant glomerulopathies are challenging, especially in immunocompromised transplanted patients.
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| http://dx.doi.org/10.1016/j.transproceed.2023.01.017 | DOI Listing |
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