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Data quality in centenarian research: The proxy-centenarian relationship and item nonresponse in the SWISS100 study.
PLoS One
January 2025
Department of Business Economics, Centre of Competence on Ageing, Health and Social Care, University of Applied Sciences and Arts of Southern Switzerland, Manno, Switzerland.
Background: In recent years, there has been a growing interest in the investigation of very old individuals. However, various challenges arise when collecting data from this age group. Given potential health and cognitive impairments and the difficulty of retrieving accurate self-reported data, involving individuals knowledgeable of the target person as proxy respondents are an invaluable solution.
View Article and Find Full Text PDFAssociations Between Complement C4, Habitual Constipation, and Sleep Disturbance in Oldest-Old and Centenarian Chinese Adults.
J Inflamm Res
January 2025
Department of Cardiology, Hainan Hospital of Chinese People's Liberation Army General Hospital, Hainan Geriatric Disease Clinical Medical Research Center, Hainan Branch of China Geriatric Disease Clinical Research Center, Sanya, People's Republic of China.
Background: Sleep disturbance is an immune-related disease, and the gut-brain axis is an important regulatory pathway. This cross-sectional study was designed to address these associations between complement C4, habitual constipation, and sleep disturbance and presents a reference for prevention and treatment of sleep disturbance.
Methods: Based on the China Hainan Centenarian Cohort Study, Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep disturbance following standard procedure.
Immune-Inflammatory Response in Lifespan-What Role Does It Play in Extreme Longevity? A Sicilian Semi- and Supercentenarians Study.
Biology (Basel)
December 2024
Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, 90134 Palermo, Italy.
Studying models of healthy aging and exceptional longevity is crucial to understanding a possible longevity signature, as most show resistance to age-related diseases. In particular, semi- and supercentenarians are a highly selected group, having survived significant adversities, including the Spanish flu and COVID-19 pandemics, indicating distinctive immune system characteristics. This paper analyzes the inflammatory scores (INFLA-score, Systemic Inflammation Response Index (SIRI)) and Aging-Related Immune Phenotype (ARIP) indicators calculated from the dataset of the DESIGN project, including 249 participants aged 19-111 years, aiming to understand the immune-inflammatory (IMFLAM) role in achieving longevity.
View Article and Find Full Text PDFFrailty and Mortality Risk Among Dogs with Extreme Longevity: Development and Predictive Validity of a Clinical Frailty Index in the Exceptional Aging in Rottweilers Study.
Animals (Basel)
December 2024
Center for Exceptional Longevity Studies, Gerald P. Murphy Cancer Foundation, West Lafayette, IN 47906, USA.
Frailty refers to a state of increased vulnerability to mortality and other adverse outcomes as a consequence of age-related decline in physiologic reserve and function. Comparative biomedical scientists are relied upon to innovate approaches to enhance understanding of the similarities and differences between humans and other animal species that can impact healthy aging. The research aim of this study was to develop a clinical frailty index (FI) in the Exceptional Aging in Rottweilers Study (EARS) and test its ability to predict all-cause mortality in elderly dogs.
View Article and Find Full Text PDFMortality causes and health spending by gender and health conditions in octogenarians, nonagenarians and centenarians in Colombia.
Sci Rep
January 2025
School of Public Health, University Medical Center Utrecht, Utrecht University & Harvard T.H. Chan, Harvard University, Utrecht, The Netherlands.
This document determines the causes of mortality (2008-2022) and calculate per capita health expenditure (2013-2021) in octogenarians, nonagenarians and centenarians in the Colombian population, considering year, gender and age group. For this nationwide retrospective descriptive observational study, epidemiological regions, urban/rural areas and morbidities were also studied. A mean of 75,552 deaths was observed from 2008 to 2022.
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