Hydroxyl radical (·OH) generated by the Fenton reaction between transition metal ions and hydrogen peroxide (HO) can induce significant cellular damage. However, the specific mechanism of ·OH-induced cell death has not been systematically studied. In this study, we reacted FeSO and FeO magnetic nanoparticles with HO and found that ·OH generated from the intracellular Fenton reaction can lead to significant cell death. The Fenton reaction between Fe with HO resulted in a shift in lipid peroxidation and cell cycle arrest. It is noteworthy that the ·OH generated from the Fenton reaction triggered severe apoptosis but did not lead to DNA double-strand breakage. Our results suggest that the Fenton reaction had acute cytotoxicity, which was primarily due to ·OH produced from the Fenton reaction inducing lipid peroxidation and apoptosis and modulating the cell cycle, but not by inducing DNA damage.
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| http://dx.doi.org/10.1016/j.bbrc.2023.02.023 | DOI Listing |
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