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Relapsing Anti-GAD65-Associated Encephalitis Responsive to Thymoma Resection, Radiation, and Immunomodulatory Therapy.
Neurohospitalist
July 2024
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Herein we describe a case of relapsing anti-GAD65-associated encephalitis which was responsive to the combination of thymoma resection, external beam radiotherapy, and immunomodulatory therapy. The case illustrates the value of remaining vigilant for the possibility of paraneoplastic syndromes in the context of anti-GAD65 antibodies and thymoma. It also illustrates that tumor-directed therapies may offer additional benefit beyond immunomodulatory therapy alone.
View Article and Find Full Text PDFParaneoplastic Neurological Syndromes as Initial Presentation of Tumors: An Eight-Year Single-Center Experience.
J Clin Med
January 2024
Second Department of Neurology, "Attikon" University Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Background: Paraneoplastic Neurological Syndromes (PNS) comprise a diverse group of disorders propagated by immune-mediated effects of malignant tumors on neural tissue.
Methods: A single-center longitudinal study was performed including consecutive adult patients treated at a tertiary academic hospital between 2015 and 2023 and diagnosed with PNS. PNS were ascertained using the 2004 and the revised 2021 PNS-Care diagnostic criteria.
Thymoma and Anti-GAD65 Antibody Positivity in Schizoaffective Disorder.
Prim Care Companion CNS Disord
February 2023
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.
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