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Natural Products From Plants Targeting Leptin Resistance for the Future Development of Anti-Obesity Agents.
Phytother Res
January 2025
Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
Obesity is a serious health threat, which has affected 16% of adults globally in 2022 and shows a trend toward youthfulness. Leptin, as a regulator of body weight, can suppress appetite and promote energy expenditure, making it potential in obesity treatment. Nevertheless, with the progress of relevant research, it is worth noting that monotherapy with leptin is not an effective strategy since most obese individuals are hyperleptinemic and resistant to leptin, where high levels of leptin fail to exert its weight-loss effects.
View Article and Find Full Text PDFParental and family presence are essential: A qualitative study of children's lived experiences with family presence in pediatric intensive care.
J Pediatr Nurs
January 2025
Dalhousie University, Department of Critical Care, Halifax, Nova Scotia, Canada. Electronic address:
Objective: To better understand critically ill children's lived experiences with family presence in the pediatric intensive care unit (PICU).
Study Design: This qualitative, interpretive phenomenological study is grounded in a Childhood Ethics ontology. We recruited children (aged 6-17 years) admitted to one of four participating Canadian PICUs between November 2021-July 2022 using maximum variation sampling.
Applying AI to Structured Real-World Data for Pharmacovigilance Purposes: Scoping Review.
J Med Internet Res
December 2024
Laboratoire d'Informatique Médicale et d'Ingénierie des Connaissances en e-Santé - LIMICS, Inserm, Université Sorbonne Paris-Nord, Sorbonne Université, Paris, France.
Background: Artificial intelligence (AI) applied to real-world data (RWD; eg, electronic health care records) has been identified as a potentially promising technical paradigm for the pharmacovigilance field. There are several instances of AI approaches applied to RWD; however, most studies focus on unstructured RWD (conducting natural language processing on various data sources, eg, clinical notes, social media, and blogs). Hence, it is essential to investigate how AI is currently applied to structured RWD in pharmacovigilance and how new approaches could enrich the existing methodology.
View Article and Find Full Text PDFEmploying foreign caregivers: A qualitative study of the perspectives of older stroke survivors.
PLoS One
January 2025
Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei, Taiwan.
Background: Global populations are aging, and the numbers of stroke survivors is increasing. Consequently, the need for caregiver support has increased. Because of this and demographic and socioeconomic changes, foreign caregivers are increasingly in demand in many developed countries.
View Article and Find Full Text PDFTowards effective functionalization of nanopores/nanochannels: the role of amidation reactions.
Chem Commun (Camb)
January 2025
State Key Laboratory of Biogeology and Environmental Geology, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan 430074, China.
In recent years, researchers have drawn inspiration from natural ion channels to develop various artificial nanopores/nanochannels, including solid-state and biological. Through imitating the precise selectivity and single molecule sensing exhibited by natural ion channels, nanopores/nanochannels have been widely used in many fields, such as analyte detection, gene sequencing and so on. In these applications, the surface functionalization of nanopores/nanochannels directly determines the effectiveness in quantitative analysis and single molecule detection.
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