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Environmental multiple sclerosis (MS) risk factors, genetic MS risk, and brain development in a general paediatric population.
J Neurol Neurosurg Psychiatry
December 2024
Neurology, MS Center ErasMS, Erasmus Medical Center, Rotterdam, Zuid-Holland, Netherlands
Article Synopsis
- Neuroaxonal loss may begin early in multiple sclerosis (MS), but it's unclear if this is due to inflammation or neurodegeneration related to genetics and environment during childhood.
- A study analyzed the impact of genetic risk scores and childhood environmental factors, like Epstein-Barr virus exposure and parental smoking, on brain MRI outcomes in children aged 9 and 13.
- Findings suggest that genetic predisposition and exposure to parental smoking can reduce brain volumes, indicating potential strategies for early MS prevention in at-risk individuals.
Enhancing Epstein-Barr virus detection in IBD patients with XAI and clinical data integration.
Comput Biol Med
January 2025
Gastroenterology Department of Xiangya Hospital, Central South University, Changsha, 410008, China; Hunan International Scientific and Technological Cooperation Base of Artificial Intelligence Computer Aided Diagnosis and Treatment for Digestive Disease, Changsha, 410011, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:
Background: There is increasing evidence of a link between Epstein-Barr virus (EBV) and gastrointestinal cancers, particularly in immunocompromised patients and those on thiopurines. Traditional endoscopic techniques have limitations in diagnosing EBV, whereas standard methods for diagnosing EBV have practical challenges in regular clinical settings related to their invasiveness and high costs.
Methods: An explainable AI (XAI) model was developed to analyze 1598 endoscopic images from 287 patients with inflammatory bowel disease (IBD), with a focus on detecting EBV infection.
EBV-positive inflammatory follicular dendritic cell sarcoma, an entity by many names.
Br J Haematol
November 2024
University of Colorado School of Medicine, Aurora, Colorado, USA.
Clinicopathological and molecular genetic insights into EBV-positive inflammatory follicular dendritic cell sarcoma.
Hum Pathol
November 2024
Department of Pathology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou University Affiliated Provincial Hospital, Fuzhou, 350001, Fujian, China. Electronic address:
Article Synopsis
- - This study focused on analyzing 12 cases of Epstein-Barr virus (EBV)-positive inflammatory follicular dendritic cell sarcoma (EBV + IFDCS) to understand its clinical and pathological features, which are not fully described.
- - Patients ranged in age from 21 to 84 years, with a predominance of females, and all were alive at the last follow-up despite some experiencing recurrence or metastasis; various subtypes were identified within the cases.
- - The study revealed significant differences in marker expressions between EBV + IFDCS and traditional follicular dendritic cell sarcoma (FDCS), along with unique genetic mutations and variations that were observed, contributing to a better understanding of this rare condition
A rare case of an EBV-positive inflammatory follicular dendritic cell tumor of the spleen.
J Surg Case Rep
September 2024
Department of Surgery, Southern Illinois University School of Medicine, Carbondale, IL, USA.
Epstein-Barr virus positive inflammatory pseudotumor follicular dendritic cell sarcoma (EBV+ FDCS) is a rare indolent neoplasm that presents primarily in the spleen and liver. We display a case of EBV+ FDCS in the spleen, its clinic-pathologic properties, and treatment. Our patient was evaluated following an incidental finding of a splenic mass on imaging after a traumatic injury.
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