AI Article Synopsis
- - An enzyme-catalyzed process was used for the asymmetric synthesis of phthalidyl esters, achieving high yields (up to 95%) and excellent enantiomeric purity (up to 99%) in a single-step reaction.
- - The method involved dynamic kinetic resolution, which allows for the efficient creation of these compounds.
- - The successful preparation of phthalidyl ester prodrugs and the ability to scale up the reaction highlight the method's practical applications in pharmaceutical development.
Article Abstract
An enzyme-catalyzed dynamic kinetic resolution strategy was applied for the asymmetric synthesis of phthalidyl esters in high yields (up to 95%) and enantiomeric purities (up to 99% ) through a direct one-pot procedure. Preparation of phthalidyl ester prodrugs and a scale-up reaction demonstrated the potential of this method for practical applications.
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| http://dx.doi.org/10.1021/acs.joc.2c02531 | DOI Listing |
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