Background: Infertility is considered as a common problem appears in about 10-12% of couples in their reproductive ages Ring finger protein 38 gene is a ubiquitin-protein ligase that can regulate Protein 53 and affect cellular motility.
Objective: Considering the role of on cellular motility and on the regulation of , the present study aimed to assess the difference between and genes expression in normozoospermic and asthenospermic samples as a diagnostic biomarker in males.
Materials And Methods: The present study was conducted among 21 asthenospermicsand 63 healthy individuals. First, the real-time polymerase chain reaction technique was applied to measure the expression level of the and genes extracted from sperm samples, and the glyceraldehyde-3phosphate dehydrogenase gene was selected as the reference gene.
Results: An increase and a decrease occurred in the level of and genes expressions in asthenospermic and normozoospermic samples, respectively. In addition, a significant difference was observed between increasing gene expression (p 0.001), reducing one, and decreasing sperm motility (p 0.001) in asthenospermic cells compared to that of normozoospermic ones.
Conclusion: Based on the results, an increase in the expression of the gene and a decrease in the expression of the gene had a significant relationship with asthenospermia in men. Therefore, it is expected that an effective step should be adopted to diagnose the asthenospermia expression pattern by using these results.
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| http://dx.doi.org/10.18502/ijrm.v20i12.12563 | DOI Listing |
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