AI Article Synopsis
- Liver cancer arises from liver diseases like injury and metabolic disorders, often linked to chronic inflammation.
- Liver macrophages are key players in managing this inflammation and the transition from liver issues to cancer.
- The review focuses on how bioactive lipids from liver cells influence inflammatory responses and contribute to both acute and chronic liver inflammation leading to cancer.
Article Abstract
Liver cancer is a malignancy developed from underlying liver disease that encompasses liver injury and metabolic disorders. The progression from these underlying liver disease to cancer is accompanied by chronic inflammatory conditions in which liver macrophages play important roles in orchestrating the inflammatory response. During this process, bioactive lipids produced by hepatocytes and macrophages mediate the inflammatory responses by acting as pro-inflammatory factors, as well as, playing roles in the resolution of inflammation conditions. Here, we review the literature discussing the roles of bioactive lipids in acute and chronic hepatic inflammation and progression to cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932286 | PMC |
| http://dx.doi.org/10.3389/fphys.2023.1098467 | DOI Listing |
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