AI Article Synopsis
- The study investigates the common microorganisms causing neonatal sepsis and the trends in antibiotic resistance patterns, based on a retrospective analysis of 344 cases from a southern India hospital between 2012 and 2017.
- Key findings reveal that the most frequent pathogens were responsible for a significant percentage of deaths, and that antibiotics like amikacin, vancomycin, and ampicillin were the most utilized.
- The research highlights the need for antibiotic stewardship policies to address and improve treatment outcomes amid increasing antimicrobial resistance in neonatal sepsis cases.
Article Abstract
Background And Aim: Inappropriate use of antibiotics may increase antimicrobial resistance (AMR) among different microorganisms and may lead to treatment failure in neonatal septicemia. The aim of this study was to recognize the most common microorganisms responsible for neonatal sepsis and to evaluate the trend of change of resistance pattern among microorganisms.
Methods: This study was done retrospectively on 344 cases diagnosed with neonatal sepsis, including both early and late onset cases, admitted to the tertiary care teaching hospital of southern India from January 2012 to July 2017. Accordingly, 231 culture positive neonatal sepsis cases were collected from hospital data base and analyzed. Culture positive cases within 72 hours of life were termed as early onset while after 72 hours were late onset. Antibiotics utilization during the period was calculated using WHO AMC tool and reported as (DDD)/100 bed days.
Results: with 56 (21.8%) and with 52 (20.2%) cases were the most frequent isolated organisms which were responsible for 55.8% and 14.6% of deaths among the study subjects respectively. Amikacin (86.7%), vancomycin (52.3%) and ampicillin (40.6%) were the most used antibiotics in terms of DDD/100 bed days.
Conclusion: The results obtained from our study have brought substantial information on the antibiotic resistance pattern among microorganisms causing neonatal sepsis. Moreover, results obtained from this study can be used for designing antibiotic stewardship policies to prevent the emergence of resistance and to improve the treatment outcome.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9924814 | PMC |
| http://dx.doi.org/10.15386/mpr-2409 | DOI Listing |
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