AI Article Synopsis
- Researchers developed probiotic-based nanoparticles called OASCLR that effectively kill over 99.97% of common bacterial pathogens, addressing both hyperactive immunocompetent and immunocompromised pneumonia.
- OASCLR helps restore lung microbiota by reducing harmful bacteria while promoting beneficial probiotics, leading to a richer and more diverse microbial environment.
- The nanoparticles enhance immune response in macrophages, improving their ability to clear pathogens and reducing inflammation in pneumonia cases.
Article Abstract
While conventional bacterial pneumonia mainly centralizes avoidance of bacterial colonization, it remains unclear how to restore the host immunity for hyperactive immunocompetent primary and immunocompromised secondary bacterial pneumonia. Here, probiotic-based nanoparticles of OASCLR were formed by coating chitosan, hyaluronic acid and ononin on living . OASCLR nanoparticles could effectively kill various clinic common pathogens and antibacterial efficiency was >99.97%. Importantly, OASCLR could modulate lung microbiota, increasing the overall richness and diversity of microbiota by decreasing pathogens and increasing probiotic and commensal bacteria. Additionally, OASCLR could target inflammatory macrophages by the interaction of OASCLR with the macrophage binding site of CD44 and alleviate overactive immune responses for hyperactive immunocompetent pneumonia. Surprisingly, OASCLR could break the state of the macrophage's poor phagocytic ability by upregulating the expression of the extracellular matrix assembly, immune activation and fibroblast activation in immunocompromised pneumonia. The macrophage's phagocytic ability was increased from 2.61% to 12.3%. Our work provides a potential strategy for hyperactive immunocompetent primary and immunocompromised secondary bacterial pneumonia.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935993 | PMC |
| http://dx.doi.org/10.1093/nsr/nwac221 | DOI Listing |
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