Alteration in lipid metabolism can result in fat accumulation in adipose tissues, which may lead to two most important human diseases, obesity and diabetes. A shift in lipid metabolism deregulates signaling pathways which regulates obesity and/or diabetes. In this study, we examined the components of insulin/ TGF-β pathways and their genetic interaction with Krüppel-like transcription factors (KLFs). Their role in energy homeostasis were discussed. We separately created genes double mutants by carrying out RNAi on ), mutants. And then conducted Oil O Red staining to assay the worms for fat deposits and examine genetic interaction between and genes. The results showed that worms bearing or and , or mutations deposit large, but similar fat levels as individual mutants. The results suggested that they target the same molecular pathway of fat storage. or RNAi worms showed higher fat deposits in worms than or mutants alone, which showed a functional interaction between and in perhaps TGF-β-like pathway. Altogether our study suggests a direct role of in insulin signaling pathway.
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| http://dx.doi.org/10.1007/s13205-023-03502-5 | DOI Listing |
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