Diesel engines are particularly harmful to the environment due to the high levels of pollution they release. This led to the discovery of a sustainable and environmentally friendly fuel source. Mahua oil transesterified into biofuel seems to be the most popular option. The possibilities for nano-additions to enhance engine performance while simultaneously lowering pollution levels are substantial. In this research, 20% by proportion mahua biodiesel (MAH B20) was mixed with varying concentrations of aluminum oxide (AlO) and cerium oxide (CeO) nanoparticles, and their joint effects on a mono-cylinder diesel engine working at a speed of 1500 revolutions per minute (rpm) were evaluated. With the use of an ultrasonic bath, the nanoparticles and MAH B20 were blended at varying concentrations and a surfactant was added for stability. The investigations concluded that the combustion and emission properties of mahua biofuel were improved because of the higher volume to surface area ratio of the combined AlO and CeO nanostructures. The best results are found when mahua biofuel is mixed with AlO and CeO each at 100 parts per million (ppm). The blend MAH B20 AL100 CE100 exhibits reduced brake specific fuel consumption (BSFC) by 3.25%, increased brake thermal efficiency (BTE) by 1.39%, and reduced emissions of hydrocarbon (HC), oxides of nitrogen (NO), and carbon monoxide (CO) by 30.73, 1.27, and 44.13%, respectively.
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http://dx.doi.org/10.1021/acsomega.2c07193 | DOI Listing |
Diabetes Metab J
September 2024
Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Backgruound: Guidelines for switching to triple combination therapy directly after monotherapy failure are limited. This study investigated the efficacy, long-term sustainability, and safety of either mono or dual add-on therapy using alogliptin and pioglitazone for patients with type 2 diabetes mellitus (T2DM) who did not achieve their target glycemic range with metformin monotherapy.
Methods: The Practical Evidence of Antidiabetic Combination Therapy in Korea (PEAK) was a multicenter, placebo-controlled, double-blind, randomized trial.
Am J Psychiatry
January 2024
Department of Psychiatry (McIntyre, Rosenblat, Mansur) and Department of Pharmacology and Toxicology (McIntyre, Rosenblat, Mansur), University of Toronto, Toronto; Brain and Cognition Discovery Foundation, Toronto (McIntyre, Kwan, Teopiz); Faculty of Medicine, University of Ottawa, Ottawa (Kwan).
Psychotropic drug-related weight gain (PDWG) is a common occurrence and is highly associated with non-initiation, discontinuation, and dissatisfaction with psychiatric drugs. Moreover, PDWG intersects with the elevated risk for obesity and associated morbidity that has been amply reported in the psychiatric population. Evidence indicates that differential liability for PDWG exists for antipsychotics, antidepressants, and anticonvulsants.
View Article and Find Full Text PDFFoods
October 2023
Laboratory of Genetics, Nature Research Centre, 08412 Vilnius, Lithuania.
The bacterial contamination of meat is a global concern, especially for the risk of infection that can lead to health issues. Artificial antibacterial compounds used to preserve fresh meat can have negative health effects. We investigated the potential of natural essential oils (EOs), namely (mint) and (cinnamon) EOs, to prevent contamination of the food pathogen, subsp.
View Article and Find Full Text PDFOrphanet J Rare Dis
September 2023
Wyss Institute, Harvard University, Boston, USA.
Background: We consider two key challenges that early-stage biotechnology firms face in developing a sustainable financing strategy and a sustainable business model: developing a valuation model for drug compounds, and choosing an appropriate operating model and corporate structure. We use the specific example of Unravel Biosciences-a therapeutics platform company that identifies novel drug targets through off-target mechanisms of existing drugs and then develops optimized new molecules-throughout the paper and explore a specific scenario of drug repurposing for rare genetic diseases.
Results: The first challenge consists of producing a realistic financial valuation of a potential rare disease repurposed drug compound, in this case targeting Rett syndrome.
Life (Basel)
July 2023
Department of Medical Science, Soonchunhyang University, 22 Soonchunhyang-ro, Asan 31538, Republic of Korea.
Psoriasis, a chronic and autoimmune inflammatory disorder of the skin, has been often underdiagnosed and underestimated despite its prevalence and considerable negative effects on the quality of life. In this study, the anti-inflammatory activity of fruit extract (FFE) was investigated against LPS-stimulated RAW 264.7 cells.
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