Objectives: The objective of this work is to investigate the impact of the pelvicalyceal anatomical system (PCS) on calyceal stone formation and surgical outcomes of endoscopic combined intrarenal surgery (ECIRS) for renal and/or proximal ureteral stones with a diameter >15 mm.
Patients And Methods: PCS was classified as Type I (single pelvis) or Type II (divided pelvis) according to the simple anatomical Takazawa classification. Using prospectively collected data from January 2016 to April 2020, 219 patients were retrospectively reviewed. After excluding patients who underwent a staged procedure, had hydronephrosis greater than grade 2, prior nephrostomy tubes, and failed to access the renal collecting system, 115 patients (Type I: 81, Type II: 34) were included, and the distribution of calyceal stones and surgical outcomes in ECIRS were compared between Types I and II PCS.
Results: The median number of renal stone calyces in the Type II group was significantly more than that in the Type I group ( = 0.016). In particular, the Type II group possessed more upper stone calyces. Multivariate logistic regression analysis revealed that Type II PCS was associated with an increased odds ratio (OR) for the presence of upper stone calyces (OR: 2.93, = 0.018). The stone-free (SF) status at 1 month after surgery, confirmed by abdominal plain radiography, was significantly higher in the Type I group compared with that in Type II (67.9% vs. 39.4%, respectively; = 0.006). The requirement for additional surgical interventions was significantly higher in the Type II group compared with that in Type I (35.4% vs. 7.4%, respectively; < 0.001). Multivariate analysis revealed that the number of stone calyces (OR: 4.26; = 0.001) and Type II PCS (OR: 3.43; = 0.009) were independent predictors of residual stones after ECIRS.
Conclusion: We first revealed that the anatomic properties of PCS play a role in both upper calyceal stone formation and in the success of the ECIRS procedure. Because the SF rate in Type II PCS was significantly lower than that in Type I PCS, additional percutaneous nephrolithotomy tracts might be required, even for ECIRS.
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http://dx.doi.org/10.1002/bco2.209 | DOI Listing |
JAMA Dermatol
March 2025
Service de Dermatologie et Allergologie, Faculté de Médecine, Sorbonne Université, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Paris, France.
Importance: VEXAS syndrome (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is a monogenic disease caused by UBA1 somatic variants in hematopoietic progenitor cells, mostly involving adult men. It is associated with inflammatory-related symptoms, frequently involving the skin and hematological disorders. Recently described myelodysplasia cutis (MDS-cutis) is a cutaneous manifestation of myelodysplasia in which clonal myelodysplastic cells infiltrate the skin.
View Article and Find Full Text PDFEpilepsia
March 2025
Neuroscience and Medical Genetics Department, Meyer Children's Hospital IRCCS, Florence, Italy.
Objective: This study was undertaken to prospectively assess the frequency and type of psychiatric disorders (PDs) in pediatric surgical candidates and evaluate the effects of epilepsy surgery on their psychopathological profile.
Methods: This is a prospective controlled study. Psychopathology was assessed using both diagnostic interviews and questionnaires completed by clinicians, parents, and whenever possible, patients, at baseline (T0) and 1 year after surgery in operated patients (T1) and 1 year after the first evaluation in a control group of nonoperated patients (T1).
Zoo Biol
March 2025
Taronga Institute of Science and Learning, Taronga Conservation Society Australia, Dubbo and Sydney, New South Wales, Australia.
Management of African wild dogs (Lycaon pictus) in zoos involves several challenges, including the difficulty of providing appropriate stimulation and enrichment for naturally wide-ranging, energetic, cursorial hunters. Perhaps consequently, zoo packs can exhibit bouts of extreme intra-pack aggression rarely seen in the wild. As with other species, considerable efforts are required to balance the retention and exhibition of wild-type behaviors, against ensuring that the nutritional and welfare needs of individual group-living animals are met.
View Article and Find Full Text PDFClin Pediatr (Phila)
March 2025
Pediatric Endocrinology, Kings County, NYC Health + Hospitals, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Mixed presentation of diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) has been reported in up to 27% of hyperglycemic emergencies. This 15-year retrospective chart review describes clinical features, risk factors, and outcomes among children presenting with hyperglycemic emergencies at our center. Out of 322 patients, 92% were Afro-Caribbean or Black with a mean age of 13.
View Article and Find Full Text PDFPurpose: No literature consensus was found about the best treatment of acute Rockwood type III acromioclavicular joint (ACJ) dislocation. In particular, the advantages and disadvantages between conservative treatment and surgery are not sufficiently quantified in the current literature.
Methods: A systematic literature search was conducted using PubMed, Web of Science and Embase in March 2024.
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