AI Article Synopsis
- Glaucoma is a leading cause of blindness, affecting both the optic nerve pathway and the visual cortex, but the dynamic connectivity of the visual cortex in primary angle-closure glaucoma (PACG) patients was not previously studied.
- A study involving 34 PACG patients and 34 healthy controls used a sliding window method to examine dynamic functional connectivity (dFC) changes in the primary visual cortex (V1).
- Results indicated that PACG patients exhibited increased dFC between V1 and the calcarine region, suggesting heightened variability in functional connectivity in the visual network among these patients.
Article Abstract
Purpose: Glaucoma is the main blindness-causing disease in the world. Previous neuroimaging studies demonstrated that glaucoma not only causes the loss of optic ganglion cells but also leads to the abnormal function of the optic nerve pathway and the visual cortex. However, previous studies also reported that patients with glaucoma have dysfunction in the visual cortex in a static state. Whether or not patients with primary angle-closure glaucoma (PACG) were accompanied by dynamic functional connectivity (FC) changes in the primary visual cortex (V1) remains unknown.
Methods: A total of 34 patients with PACG (23 men and 11 women) and 34 well-matched healthy controls (HCs) were enrolled in the study. The dynamic functional connectivity (dFC) with the sliding window method was applied to investigate the dynamic functional connectivity changes in the V1.
Results: Compared with HCs, patients with PACG showed increased dFC values between left V1 and bilateral calcarine (CAL). Meanwhile, patients with PACG showed increased dFC values between right V1 and bilateral CAL.
Conclusion: Our study demonstrated that patients with PACG showed increased dFC within the visual network, which might indicate the increased variability FC in the V1 in patients with PACG.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932926 | PMC |
| http://dx.doi.org/10.3389/fnins.2023.1131247 | DOI Listing |
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