AI Article Synopsis
- The study aimed to assess if extremely low gestation neonates (ELGANs) have higher survival odds without major health issues when born to mothers with chronic hypertension or hypertensive disorders of pregnancy compared to those without hypertension.
- Data was collected retrospectively from a large national research network, focusing on ELGANs born at 22-28 weeks gestation or weighing 401-1000 g, and survival without morbidity was the primary outcome measured.
- The findings indicated that after adjusting for various factors, maternal hypertension did not significantly improve survival rates without morbidity for ELGANs when compared to those born to mothers without hypertension.
Article Abstract
Objective: Evaluate if odds of survival without major morbidity are higher among extremely low gestation neonates (ELGANs) born to mothers with chronic hypertension (cHTN) or hypertensive disorders of pregnancy (HDP) compared to ELGANs born to mothers without hypertension (HTN).
Study Design: Retrospective study of prospectively collected data from the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Included children had a birthweight of 401-1000 g and/or gestational age of 22 to 28 wks. The primary outcome was survival to discharge without major morbidity. Multivariable regression models were used to compare outcomes among ELGANs born to women with cHTN, HDP, and no HTN.
Results: Survival without morbidities for newborns of mothers with no HTN, cHTN and HDP (29.1%, 32.9%, 37.0% respectively) did not differ after adjustment.
Conclusion: After adjusting for contributing variables maternal HTN is not associated with improved survival free of morbidity among ELGANs.
Trials Registration: clinicaltrials.gov Identifier: NCT00063063 (generic database).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10107366 | PMC |
| http://dx.doi.org/10.1038/s41372-023-01631-6 | DOI Listing |
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