LINC00462; a long intergenic non-coding RNA located on chromosome chr13:48,576,973-48,590,587 is a member of long non-coding RNA (lncRNA) that is participated in different human disorders such as pancreatic cancer and hepatocellular carcinoma. LINC00462 can act as competing endogenous RNAs (ceRNAs), to sponge different MicroRNAs (miRNAs) such as miR-665. Dysregulation of LINC00462 can promote cancer development, progression, and metastasis. LINC00462 can also bind directly with genes and proteins to regulate different pathways, including STAT2/3 and PI3K/AKT pathways to affected tumor progression. In addition, aberrant LINC00462 levels can be important cancer-specific prognostic and diagnostic markers. In this review, we summarize the most recent studies on the role of LINC00462 in different disorders and demonstrated the role of LINC00462 in tumorigenesis.
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A comprehensive review of the role of LINC00462 in human disorders.
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March 2023
National Institute of Genetic Engineering and Biotechnology, Tehran, Islamic Republic of Iran; Department of Oncology, The First Affiliated Hospital of Dalian Medical University, Dalian, PR China.
LINC00462; a long intergenic non-coding RNA located on chromosome chr13:48,576,973-48,590,587 is a member of long non-coding RNA (lncRNA) that is participated in different human disorders such as pancreatic cancer and hepatocellular carcinoma. LINC00462 can act as competing endogenous RNAs (ceRNAs), to sponge different MicroRNAs (miRNAs) such as miR-665. Dysregulation of LINC00462 can promote cancer development, progression, and metastasis.
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Gastroenterology Department, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Hepatocellular carcinoma (HCC) is one of the most common types of malignancy and is associated with high mortality. Prior research suggests that long non-coding RNAs (lncRNAs) play a crucial role in the development of HCC. Therefore, it is necessary to identify lncRNA-associated therapeutic biomarkers to improve the accuracy of HCC prognosis.
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Aging (Albany NY)
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Department of Cell-gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510000, China.
Long noncoding RNAs (lncRNAs), such as LINC00462, HOTAIR, and MALAT1, are significantly upregulated in hepatocellular carcinoma (HCC) tissues. However, lncRNA expression in the serum of HCC patients is still unclear. To identify candidate lncRNAs for HCC diagnosis, we purified exosomal total RNA from the serum of healthy volunteers (controls) and hepatitis, cirrhosis, and HCC patients.
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Cell Death Dis
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School of Integrative Medicine, Tianjin Traditional Medical University, 300193, Tianjin, China.
Emerging evidence has identified that long non-coding RNAs (lncRNAs) may play an important role in the pathogenesis of many cancers, pancreatic cancer (PC) included. However, the role of linc00462 in PC remains unclear. The aim of our present study was to investigate the potential functions of linc00462 in PC and to identify the underlying mechanisms of action.
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Medical College of Soochow University, Suzhou, Jiangsu, China; Department of General Surgery, Wenzhou No. 3 Clinical Institute of Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou, Zhejiang, China. Electronic address:
Background: Hepatocellular carcinoma (HCC) represents one of the most common malignancies worldwide. In two pubic long noncoding RNA (lncRNA) profiling studies of HCC, linc00462 was consistently upregulated. We analyzed the clinical significance and biological role of linc00462 in HCC.
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