Digital contact tracing (DCT) applications have been introduced in many countries to aid the containment of COVID-19 outbreaks. Initially, enthusiasm was high regarding their implementation as a non-pharmaceutical intervention (NPI). However, no country was able to prevent larger outbreaks without falling back to harsher NPIs. Here, we discuss results of a stochastic infectious-disease model that provide insights in how the progression of an outbreak and key parameters such as detection probability, app participation and its distribution, as well as engagement of users impact DCT efficacy informed by results of empirical studies. We further show how contact heterogeneity and local contact clustering impact the intervention's efficacy. We conclude that DCT apps might have prevented cases on the order of single-digit percentages during single outbreaks for empirically plausible ranges of parameters, ignoring that a substantial part of these contacts would have been identified by manual contact tracing. This result is generally robust against changes in network topology with exceptions for homogeneous-degree, locally-clustered contact networks, on which the intervention prevents more infections. An improvement of efficacy is similarly observed when app participation is highly clustered. We find that DCT typically averts more cases during the super-critical phase of an epidemic when case counts are rising and the measured efficacy therefore depends on the time of evaluation.
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http://dx.doi.org/10.1371/journal.pdig.0000149 | DOI Listing |
PLoS One
January 2025
Agència de Salut Pública de Barcelona (ASPB), Barcelona, Spain.
Background: In May 2022, after the suspension of the mobility restrictions due to the COVID-19 pandemic, the first outbreak of MPOX virus, transmitted from human to human, was detected outside of Africa, affecting mostly sexually active men who have sex with men. Our aim is to report the first outbreak of MPOX in Barcelona city in the period from 5/2022 to 5/2023 and the subsequent surge of cases in 8/2023.
Methods: We performed a descriptive study of all notified cases in city residents, obtained through epidemiological surveys.
BMC Infect Dis
January 2025
Emerging Pathogens Institute, University of Florida, 2055 Mowry Road, PO Box 100009, Gainesville, FL, 32610, USA.
Background: Cluster and contact investigations aim to identify and treat individuals with tuberculosis (TB) and latent TB infection (LTBI). Although genotyped cluster investigations may be superior to contact investigations in generating additional epidemiological links, this may not necessarily translate into reducing infections. Here, we investigated the impact of genotyped cluster investigations compared to standard contact investigations on the LTBI care cascade in a low incidence setting.
View Article and Find Full Text PDFNarra J
December 2024
Doctoral Program of Development Extension and Community Empowerment, School of Postgraduate Studies, Universitas Sebelas Maret, Surakarta, Indonesia.
Tuberculosis (TB) remains a significant global health challenge, especially for children. The aim of this scoping review was to investigate the role of mothers in preventing childhood TB transmission and highlight effective strategies and associated barriers. A systematic literature search was conducted using PubMed, Web of Science, and Scopus, covering articles up to January 17, 2024.
View Article and Find Full Text PDFTunis Med
January 2025
Laboratory of viruses, vectors and hosts: LR20IPT10, Institut Pasteur de Tunis, University of Tunis El Manar, 13, Place Pasteur, 1002 Tunis Belvédère, Tunisia.
Since the World Health Organization declared the Coronavirus Disease 2019 (COVID-19) pandemic as an international concern of public health emergency in the early 2020, several strategies have been initiated in many countries to prevent healthcare services breakdown and collapse of healthcare structures. The most important strategy was the increased testing, diagnosis, isolation, contact tracing to identify, quarantine and test close contacts. In this context, finding a rapid, reliable and affordable tool for COVID-19 screening was the main challenge to address the pandemic.
View Article and Find Full Text PDFInfect Genet Evol
January 2025
Department of Epidemiology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand. Electronic address:
The growing issue of drug resistance, particularly multidrug-resistant TB (MDR-TB), has exacerbated this problem. The rise of drug resistance TB is a severe global health concern. In Thailand, a persistent community outbreak of primary MDR-TB has been confirmed in the Tha Maka district of Kanchanaburi province, with an increasing prevalence of MDR-TB among newly diagnosed pulmonary tuberculosis cases.
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