Ichthyoses are a heterogeneous group of skin disorders featuring erythroderma and generalized scaling. The relationship between ichthyosis and melanoma has not been well-characterized. Herein we present a unique case of acral melanoma of the palm developing in an elderly patient with congenital ichthyosis vulgaris. Biopsy revealed a superficially spreading melanoma with ulceration. To the best of our knowledge, no acral melanomas have been reported so far in patients with congenital ichthyosis. Nevertheless, considering the potential for invasion and metastasis, patients with ichthyosis vulgaris should undergo regular clinical and dermatoscopic screening for melanoma.

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